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Mark Broadnax
Mark Broadnax

Where To Buy Ace For Horses



Objectives: The aim of the present study was to quantify by accelerometry the trotting pattern of adult horses sedated with two different doses of acepromazine, in order to assess the use of this drug in equine lameness evaluations.




where to buy ace for horses


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Methods: Seven mature horses were used and three treatments were administered to each horse: saline solution, acepromazine (0.01 mg/kg), and acepromazine (0.02 mg/kg). The portable gait analyzer used consisted of three orthogonal accelerometers that measure accelerations along the dorsoventral, longitudinal, and lateral axes. Baseline values were obtained and after treatment, accelerometric recordings were repeated every five minutes during the first 20 minutes after the injection and then every 10 minutes thereafter for two hours. Ground-to-lip distance was also measured.


Results: Administration of acepromazine decreased some of the variables investigated and differences between doses were observed. Speed, stride frequency, and stride length were significantly reduced following treatments. For coordination parameters, no significant differences among values were observed. Energetic variables suffered only weak reductions whereas ground-to-lip distance values were significantly decreased up to 120 minutes after treatment.


Clinical significance: Acepromazine produces significant alterations in the gait pattern with differences between doses, but it does not affect coordination variables in normal unexcited horses, and at a dose of 0.01 mg/kg may be the tranquilizer of choice for evaluating lameness in this setting.


Acepromazine is a rapid-acting tranquilizer used as an aid for controlling fractious horses during examination, treatment, trailer loading, and transportation. Acepromazine is also commonly used in conjunction with local anesthesia for various surgical procedures, including castration, removal of skin tumors, ocular surgery, and neurectomy.


Acepromazine is sometimes prescribed for laminitis because it lowers blood pressure by dilating small blood vessels, thereby improving circulation in the hoof. Some veterinarians prescribe Acepromazine for horses that are prone to tie up as a preventive measure or as a part of treatment.


Paralysis of the retractor penis muscle has been noted with the use of this class of tranquilizers. This risk should be considered prior to the administration of Acepromazine Maleate Injection to male horses. Dosage should be limited to the minimum amount necessary for the desired effect. Note that at the time of administration it is normal to observe the reversible protrusion of the penis. The irreversible paralysis of the retractor penis muscle may occur when a tranquilizer is used in conjunction with testosterone (or in stallions).


Acepromazine, often called simply Ace, is commonly used to tranquilize horses for veterinary procedures. However, its use in male horses can cause penile prolapse, or an inability to retract the penis back into the sheath. This effect is desire


Acepromazine, often called simply Ace, is commonly used to tranquilize horses for veterinary procedures. However, its use in male horses can cause penile prolapse, or an inability to retract the penis back into the sheath. This effect is desired in some instances, such as when acepromazine helps the horse "let down" for sheath cleaning.


Additionally, acepromazine is used as a vasodilator in the treatment of laminitis (founder). It is also sometimes used to treat horses experiencing Equine Exertional Rhabdomyolysis (Tying up Syndrome).


Reserpine was commonly sold as Serpasil, a long acting tranquilizer that had effects lasting up to 30 days. Serpasil was used is the horse industry to help horses in lay-up for injuries but also came into unscrupulous use as a long-acting tranquilizer in horses being sold.The unsuspecting buyer leaves the sale with a calm horse that weeks later has become a completely different animal.


The problem will all of the above pharmaceuticals in that they are prohibited for use in competition under many jurisdictions. Many elite horse competitions fall under the Drugs and Medications Rule of the United States Equestrian Federation, American Quarter Horse Association, FEI, National Trail riding Council, and other where any substance that causes sedation is a prohibited substance.


To evaluate potential calming effects of alpha-casozepine on horses, we blindly compared behavior and training efficiency of adult semi-feral ponies treated with either alpha-casozepine or control supplement during transition to domestic management and handling. Six ponies (three matched pairs) aged 2 to 8 years that had been reared and kept since birth under semi-feral social and environmental conditions were given either alpha-casozepine (1000 mg orally once daily for ponies weighing 160 to 205 kg) or control supplement, beginning 5 days before being moved to a domestic facility for a 2-week introduction to stabling, haltering, leading, tethering, social separation, stall confinement, grooming, simulated girthing, lifting feet, health care treatments, and transportation. Objective quantitative behavior measures (latencies to complete tasks, avoidance responses, and nervous defecations) were derived from video-recorded handling sessions. For each of the 14 sessions, ponies were ranked 1 (best) to 6 (poorest) for calm, compliance, and acclimation/skill progress. All human-animal interactions,video analyses, and rankings were done blindly to supplement assignments. For most daily sessions across the 2-week training period, each of the three alpha-casozepine-treated ponies performed better than their matched control counterparts, and they also had the top three sums of daily session ranks, with a mean of 35.2 compared with 62.8 for control ponies. At 6 weeks after the 2-week training period, the alpha-casozepine-treated ponies retained the best three sum of ranks for the seven specific skills re-assessed at that time. These results provide evidence of the benefit of alpha-casozepine supplementation to horses undergoing potentially stressful situations inherent to domestic management.


In other words, horses on Casozepine while in training learned their lessons quicker and required fewer training sessions. In addition when placed back in training horses previously trained under the influence of Casozepine had better recall of their previous lessons.


In 2014 CGES participated in a trial using Casozepine prior to its release in the US market. We asked multiple horse owners to try the product in as many situations as possible. This included hunter-jumpers, barrel racing horses, trail horses, ropers and gaited show horses. Horses under the influence of Casozepine are alert with no incoordination. They show a marked reduction in anxiety and reactivity to stimuli.


Acepromazine maleate injection, a potent neuroleptic agent with a low order of toxicity, is of particular value in the tranquilization of dogs, cats and horses. Its rapid action and lack of hypnotic effect are added advantages. According to Baker,1 the scope of possible applications for this compound in veterinary practice is only limited by the imagination of the practitioner.


In horses, paralysis of the retractor penis muscle has been associated with the use of phenothiazine-derivative tranquilizers. Such cases have occurred following the use of Acepromazine maleate injection.


This risk should be duly considered prior to the administration of Acepromazine maleate injection to male horses (castrated and uncastrated). When given, the dosage should be carefully limited to the minimum necessary for the desired effect. At the time of tranquilization, it is not possible to differentiate between reversible protrusion of the penis (a normal clinical sign of narcosis) and the irreversible paralysis of the retractor muscle. The cause of this side reaction has not been determined. It has been postulated that such paralysis may occur when a tranquilizer is used in conjunction with testosterone (or in stallions).


Good to excellent results were reported1,4,5 in dogs, cats and horses given Acepromazine maleate injection for restraint during examination, treatment and minor surgery and for preanesthetic sedation. In dogs, the drug reportedly4 helps control convulsions associated with distemper.


In both dogs and cats, good to excellent results were obtained4 when acepromazine maleate tablets were used to control nervousness, excessive vocalization, neurotic and excitable behavior, vomiting associated with motion sickness, coughing and itching caused by dermatitis. In horses, Bauman6 had good results using the drug as an aid in the control of painful spasm due to colic. Other practitioners7,8 found the drug useful as a preanesthetic sedative for nervous or aggressive horses, but it had to be administered while the animals were quiet and not in an excited state. In a trial9 on more than 200 horses with a wide variety of disorders, Acepromazine maleate injection proved to be both effective and safe.


Neuroleptanalgesia refers to an effect produced by the combination of opioids and tranquilizers, or sedative drugs and this combined administration appears to minimize the mentioned excitatory consequences [7]. Alpha-2 adrenergic agonists [8,9] and phenothiazines [7,8,10] have both been used, added to opioids, in order to ameliorate the possible central nervous system (CNS) excitation in horses [11]. It is considered that this locomotor effect results from dopaminergic activity [12] and that the administration of acepromazine, due to phenothiazine blockade of central and peripheral adrenergic and dopaminergic receptors [3], reduces the locomotor response. In fact, the administration of acepromazine, due to its antidopaminergic effect, blocked the locomotor effects of fentanyl and morphine in horses [13].


It has been described that the reasons for a co-administration of a sedative drug with opioids are the lack of predictability, the inability to produce desired effects, and the development of side effects, especially excitement and ataxia at higher doses [10]. The purpose of our study was to demonstrate changes occurring in the locomotor pattern after co-administration of acepromazine and morphine while treating non-painful horses. 041b061a72


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